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MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino acid peptide encoded by the mitochondrial genome that has emerged as a promising subject in biomedical research. Discovered in 2015, MOTS-c has been found to play important roles in regulating metabolism, insulin sensitivity, and energy homeostasis. Research has shown that MOTS-c can improve glucose metabolism in skeletal muscle, reduce obesity, and potentially delay age-related physical decline.
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