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Tesamorelin is a synthetic 44 amino acid polypeptide analog of GHRH. It has been specifically developed to reduce excess abdominal fat in HIV patients with lipodystrophy. Tesamorelin works by activating GHRH receptors in the pituitary gland, leading to the synthesis and release of growth hormone. This, in turn, stimulates the production of insulin-like growth factor-1 (IGF-1) in the liver, which mediates many of the effects of growth hormone.
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